By Matthew B. Nodwell, Stephan A. Sieber (auth.), Stephan A. Sieber (eds.)
ABPP method: advent and assessment, by way of Matthew B. Nodwell und Stephan A. Sieber Activity-Based Protein Profiling for common Product objective Discovery, by means of Joanna Krysiak und Rolf Breinbauer Photoaffinity Labeling in Activity-Based Protein Profiling, by way of Paul P. Geurink, Laurette M. Prely, Gijs A. van der Marel, Rainer Bischoff und Herman S. Overkleeft software of Activity-Based Protein Profiling to the research of Microbial Pathogenesis, by way of William P. Heal und Edward W. Tate practical research of Protein pursuits by way of Metabolomic techniques, by way of Yun-Gon Kim und Alan Saghatelian
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Jones JE, Causey CP, Knuckley B et al (2009) Protein arginine deiminase 4 (PAD4): current understanding and future therapeutic potential. Curr Opin Drug Discov Devel 12:616–627 123. Vossenaar ER, van Venrooij WJ (2004) Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis. Arthritis Res Ther 6:107–111 ABPP Methodology: Introduction and Overview 39 124. Luo Y, Arita K, Bhatia M et al (2006) Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.
Angew Chem Int Ed Engl 49:2680–2698 14. Barglow KT, Cravatt BF (2007) Activity-based protein profiling for the functional annotation of enzymes. Nat Methods 4:822–827 15. Dennehy MK, Richards KA, Wernke GR et al (2006) Cytosolic and nuclear protein targets of thiol-reactive electrophiles. Chem Res Toxicol 19:20–29 16. Scaloni A, Ferranti P, De Simone G et al (1999) Probing the reactivity of nucleophile residues in human 2,3-diphosphoglycerate/deoxy-hemoglobin complex by aspecific chemical modifications.
11). Using this probe library, a virulence-associated secretory antigen, SsaA2 from methicillin-resistant Staphylococcus aureus (MRSA) was identified . 1,3-Cyclohexadiones Reactive oxygen species can act as second messengers in signal transduction pathways that regulate cellular processes such as cell growth, differentiation, and migration [165–167]. It is likely that cysteine residues in proteins are the intracellular targets of oxidation, acting as redox sensors in the cell . The first product in the reaction of cysteine and H2O2 is a sulfenic acid, which can then be reduced back to the thiol, or further oxidized to sulfinic or sulfonic acids .
Activity-based protein profiling by Matthew B. Nodwell, Stephan A. Sieber (auth.), Stephan A. Sieber (eds.)