By J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle
Every one quantity of Advances in Pharmacology offers a wealthy choice of studies on well timed subject matters. Emphasis is put on the molecular bases of drug motion, either utilized and experimental.
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The Sag protein encoded by Mtv-7, which is highly homologous to that of the SW virus, also causes the deletion of VP6+ T cells. Held and colleagues (1993b) showed that inbred mouse strains containing Mtv-7 were resistant to the SW but not the MMTV(C3H) virus. That Sag presentation was critical to the milk-borne infection pathway also explained why C57BL mice were resistant to milk-borne MMTV(C3H). Most strains of mice have germ line copies of two different M H C Class I1 genes, I-E and I-A. However, C57BL mice and related strains have a genomic deletion of their I-E gene.
A ) Endogenous MMTVs that are transmitted through the germ line can eithcr produce functional virions or sustain mutations, usually in the protein-coding regions, that prevent rhcir transmission. Mice with active, unmutated endogenous MMTVs cannot he freed of virus by nursing on nonviremic mothers. MMTV infcction of mice that have exogenous and not functional endogenous proviruses can lose the milk-borne virus aftcr nursing o n virus-free mothers. (€3) The retroviral infection of cclls. Retroviruses usually infect somatic cells; in the rare case where infection of a germ cell occurs, the provirus is passed to subsequcnt gcncrations.
328, 1313-1316. 18 Walter E. Smalley and Raymond N. , Rimm, E. , Stampfer, M. , Colditz, G. , and Willett, W. C. Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann. Intern. Med. 121, 241-246. , Egan, K. , Hunter, D. , Stampfer, M. , Colditz, G. A,, Willett, W. , and Speizer, F. E. Aspirin and the risk of colorectal cancer in women. N. Engl. J . Med. 333, 609-614. Greenberg, E. , Baron, J. , Freeman, D. H. , Mandel, J. , and Haile, R. Reduced risk of large-bowel adenomas among aspirin users.
Advances in Pharmacology, Vol. 39 by J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle